Ashwagandha 500mg

Ashwagandha ou Ginseng indiano, tem sido utilizada há séculos pela medicina Ayurvédica para aumentar a longevidade e vitalidade. Pesquisas mostram os seus diversos usos, considerando-o um ativo polifarmacológico, onde os seus constituintes terapêuticos promovem diversos benefícios ao organismo: atividade antioxidante, antitumoral, antiinflamatória, afrodisíaca, estimulante, imunomoduladora, antiestresse e adaptógena (MISHRA, 2000).

Devido as suas propriedades adaptógenas, Ashwagandha tem-se mostrado eficaz no tratamento coadjuvante dos sintomas do estresse, depressão e ansiedade em indivíduos saudáveis. Devido as suas propriedades terapêuticas, ela possui excelente efeito Neuroprotetor, podendo ser uma alternativa promissora para o tratamento de uma variedade de doenças neurodegenerativas tais como Alzheimer e Parkinson.

Al-Fatimi M, Friedrich U, Jenett-Siems K. Cytotoxicity of plants used in traditional medicine in Yemen. Fitoterapy. 2005; 76(3-4):355-358. Anon. Monograph. Withania somnifera. Alter Med Rev. 2004 Jun; 9(2):211-4. Battacharya A, Ghosal S, Bhattacharya SK. Antioxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced pertubations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex ans striatum. J Ethnopharmacol. 2001 Jan; 74(1):1-6. Bhatnagar M, Sisodia SS, Bhatnagar R. Antiulcer and antioxidante activity of Asparagus racemosa WILLD and Whithania somnifera DUNAL in rats. Ann N Y Acad Sci. 2005; 1056:261-278. Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000 Dec; 7(6): 463-9. Bhattacharya SK, Kumar S, Ghosal S. Effects of glycowithanolides from Withania somnifera on an animal model of Alzheimer´s disease and perturbed central cholinergic markers of cognition in rats. Phytother Res. 1995; 9(2): 110- 113. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Exp Biol. 1997; 35:236-239. Bone K. Clinical applications of ayurvédica and Chinese herbs. Phytoterapy Press, 1996, 137-41. Davis L, Kuttan G. Effect of Withania somnifera on cell mediated immune response in mice. J Exp Clin Cancer Res. 2002; 21:585-590. Davis L; Kuttan G. Immunomodulatory and antitumor activities of Withania somnifera. J Ethnopharmacol 2000; 71: 193-200. Ganzera M, Choudhary ML, Khan IA. Quantitative HPLC analysis of withanólides in Withania somnifera. Fitoterapy. 2003; 74(1-2): 68-76. Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J Ethnopharmacol. 2005 Jun 3; 99(2): 165-78. Ichikawa H, Takada Y, Shishodia S, Jayaprakasam B, Nair MG, Aggarwal BB. Withanoloides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suprresion of nuclear factor-kappaβ (NF-kappaβ) activation and NF-kappaβ-regulated gene expression. Molecular Cancer Therapeutics. 2006 Jun; 5(6): 1434-45. Iuvone T; Esposito G; Capasso F; Izzo A. Induction of nitric oxide synthase expression by Withania somnifera in macrophages. Life Sci. 2003; 72:1617-1625. Jain S, Shukla SD, Sharma K, Bhatnagar M. Neuroprotective effects of Withania somnifera Dunn. In Hippocampla sub-regions of female albino rat. Phytother Res. 2001 Sep; 15(6): 544-8. Khan B, Ahmad SF, Bani S, et al. Augmentation and proliferation of T lymphocytes and Th-1 cytokines by Withania somnifera in stressed mice. Int Immunopharmacol. 2006; 6:1394-1403. Kuboyama T, Tohda C, Komatsu K. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005 Apr; 144(7): 961-71. Kulkarni SK, Dhir A. Withania somnifera: a Indian ginseng. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(5): 1093-1105. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Whithania sominifera (Ashwagandha): a review. Altern Med Rev. 2000; 5:334-346. Owais M, Sharad KS, Shehbaz A, Saleemuddin M. Antibacterial effeicacy of Withania somnifera (Ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis. Phytomedicine. 2005 Mar; 12(3): 229-35. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of Ashwagandha root extract to adult male mice. J Pharm Pharmacol. 1998; 50:1065-1068. Prakash J, Gupta SK, Dinda AK, Withania somnifera root extract prevents DMBA-Induced Squamous cell carcinoma of skin in swiss albino mice. Nutr Cancer. 2009; 42:91-94 DOI: 10.1207/s15327914nc421_12.

A ashwagandha não deve ser usada por mulheres grávidas ou em amamentação, por pessoas com doenças autoimunes como artrite reumatoide ou lúpus, ou que tenham úlcera no estômago.

Ashwagandha..........500mg
Excipiente padrão qsp 1mg
(Dose p/ 1 cápsula)
 

Tomar 1 cápsula 2x ao dia ou conforme orientação do profissional habilitado.